What is methylcobalamin?

Methylcobalamin is the methylated coenzyme form of vitamin B12, a cobalt-corrinoid cofactor, supplied as a laboratory reagent.

What is studied mechanistically?

Its role as the cofactor for methionine synthase, transferring a methyl group from 5-methyltetrahydrofolate to homocysteine — the reaction linking the folate and methionine cycles in one-carbon metabolism.

Which experimental models use it?

Enzyme-activity assays for methionine synthase, one-carbon-flux studies in cell culture with isotope tracing, and defined culture-media formulation where B12 status is a controlled variable.

How does Pure Helix verify this methylcobalamin lot?

Each lot is released against a batch-specific certificate of analysis: identity by mass spectrometry (observed mass compared with the calculated monoisotopic/average mass), chromatographic purity by RP-HPLC reported as area percent at a stated wavelength, and quantity/appearance checks on the lyophilised cake. The material is light-sensitive, so identity and content are assessed on protected samples and the vial is supplied light-protected. The certificate for the exact lot shipped is linked from the COA tab and the COA database.

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Methylcobalamin (Vitamin B12 Coenzyme Form)

Coenzyme-form B12 cofactor for methylation-pathway research.

Methyl B12

10mg

Drag the vial to rotate the label

Batch-verifiedShips from U.S.Public COAResearch-grade

Form

Solution

Storage & Handling

Store at 2–8°C, protected from light.

Ships from

United States

Select size

1 options · price per mg shown

Quantity

Price

$44.99

$44.99 per vial

$155.01 away from free shipping$200+

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Research use only

This compound is not currently available for purchase. Submit a request to help guide future inventory and testing priorities.

Form

Solution

Storage & Handling

Store at 2–8°C, protected from light.

Ships from

United States

One-carbon and methionine-cycle metabolismMethylmalonyl-CoA mutase cofactor studiesHomocysteine remethylation assays

Coenzyme-form B12 cofactor for methylation-pathway research.

Methylcobalamin is the biologically active coenzyme form of vitamin B12 and serves as the cofactor for methionine synthase. It is used in cell-culture and biochemical assays examining one-carbon metabolism, homocysteine remethylation, and folate-cycle intermediates. Light-sensitive; protect from light. Research use only.

Compound identity

Methylcobalamin (Vitamin B12 Coenzyme Form)

Cofactor—A non-protein molecule — vitamin-derived, metal ion, or nucleotide — required for or supportive of enzymatic activity.

Formula

C₆₃H₉₁CoN₁₃O₁₄P

Form

Solution

Available sizes

10mg

Reconstitution

Per researcher protocol

Storage & Handling

Store at 2–8°C, protected from light.

Ships from

United States

Intended use

Research use only

Research areas

One-carbon and methionine-cycle metabolism
Methylmalonyl-CoA mutase cofactor studies
Homocysteine remethylation assays

Why researchers choose Pure Helix

Independently verified for identity and purity on a batch-specific basis.
Certificates of analysis publicly accessible by lot ID — never averaged.
Sourced through qualified manufacturing partners and shipped from the United States.
Fast shipping, always tracked, shipped from the United States.

Every lot

Batch-specific certificate of analysis, retrievable by lot ID.

Open COA database →

Reference

Research and documentation

Methyl B12 molecular reference

Formula, mass, sequence and documented lots

Quality & testing methods

Identity, purity and net content methods used for every lot

How to read a certificate of analysis

Field-by-field walkthrough of a Pure Helix COA

Backordered · Stage 03 of 06

Where this lot is in the release process

03 · En Route to LabStage 03 of 06

01
Backorder confirmed
Your product is reserved from the incoming lot.
02
Arriving for testing · ~6 days
Incoming lot is expected to reach our testing queue within 6 days.
03
Sample en route to lab
A representative sample is being sent for independent analytical testing.
04
Independent testing · 3–5 days
Identity, purity, and applicable analytical testing are completed.
05
Results verified
Results are reviewed and the certificate of analysis is published.
06
Ready to ship
Verified inventory is released and your order is prepared for shipment.

Timeframes are estimates.

Methyl B12 · 10mg

$44.99