What is SS-31 peptide?

SS-31 is a synthetic cationic, aromatic tetrapeptide (D-Arg-dimethylTyr-Lys-Phe-NH₂) from the Szeto-Schiller series, also known in the research literature as elamipretide. Supplied as lyophilised research material.

How does SS-31 interact with cardiolipin in experimental models?

Its alternating cationic/aromatic motif is reported to associate selectively with cardiolipin in the inner mitochondrial membrane. Published work uses that interaction to study cristae architecture, electron-transport-chain organisation and membrane-potential readouts in isolated mitochondria and cell cultures.

Why are mitochondria central to SS-31 research, and what evidence exists?

Because the target lipid is essentially mitochondria-specific. The literature spans isolated mitochondria, cultured cells under oxidative challenge, rodent models, and clinical studies of elamipretide in primary mitochondrial disease, reported by their sponsors and investigators.

How does Pure Helix verify this SS-31 lot?

Each lot is released against a batch-specific certificate of analysis: identity by mass spectrometry (observed mass compared with the calculated monoisotopic/average mass), chromatographic purity by RP-HPLC reported as area percent at a stated wavelength, and quantity/appearance checks on the lyophilised cake. The certificate for the exact lot shipped is linked from the COA tab and the COA database.

SS-31 (Elamipretide, Cardiolipin-Binding Tetrapeptide)

Cardiolipin-targeting tetrapeptide for mitochondrial membrane research.

SS-31

10mg

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Batch-verifiedShips from U.S.Public COAResearch-grade

Form

Lyophilized powder

Storage & Handling

Store lyophilized at -20°C.

Ships from

United States

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SKU SS10Lot PH-260529View COA for this lot →

Quantity

1

Price

$59.99

$59.99 per vial

$140.01 away from free shipping$200+

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Identity & purity per lot

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Batch-specific COA

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By adding to cart, purchaser certifies the materials are being acquired solely for legitimate laboratory research purposes. Not for human or veterinary use.

Form

Lyophilized powder

Storage & Handling

Store lyophilized at -20°C.

Ships from

United States

Cardiolipin-binding and inner-membrane integrity studiesMitochondrial ROS and respiration assaysBioenergetic recovery models

Cardiolipin-targeting tetrapeptide for mitochondrial membrane research.

SS-31 is a cell-permeable tetrapeptide that associates selectively with cardiolipin in the inner mitochondrial membrane. It is used in isolated mitochondria and cultured cells to study cristae architecture, electron-transport efficiency, reactive-oxygen-species production, and ATP output. Supplied as a lyophilized powder. Research use only.

Compound identity

SS-31 (Elamipretide, Cardiolipin-Binding Tetrapeptide)

Single Peptide—A defined chain of amino acids supplied as one compound, with its own sequence and molecular formula.

Formula

C₃₂H₄₉N₉O₅

Form

Lyophilized powder

Available sizes

10mg, 50mg

Reconstitution

Per researcher protocol

Storage & Handling

Store lyophilized at -20°C.

Ships from

United States

Intended use

Research use only

Research areas

Cardiolipin-binding and inner-membrane integrity studies
Mitochondrial ROS and respiration assays
Bioenergetic recovery models

Why researchers choose Pure Helix

Independently verified for identity and purity on a batch-specific basis.
Certificates of analysis publicly accessible by lot ID — never averaged.
Sourced through qualified manufacturing partners and shipped from the United States.
Fast shipping, always tracked, shipped from the United States.

Every lot

Batch-specific certificate of analysis, retrievable by lot ID.

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Reference

Research and documentation

SS-31 molecular reference

Formula, mass, sequence and documented lots

Quality & testing methods

Identity, purity and net content methods used for every lot

How to read a certificate of analysis

Field-by-field walkthrough of a Pure Helix COA

Lot certificatesPH-260529 Verify on Bioviridian