KPV is the C-terminal tripeptide lysine-proline-valine of alpha-melanocyte-stimulating hormone (α-MSH), supplied as a lyophilised research material.

What is the amino acid sequence of KPV, and how does it relate to α-MSH?

Lys-Pro-Val — residues 11-13 of α-MSH, calculated average mass ≈343.4 Da. It is studied as the minimal fragment retaining some of the anti-inflammatory activity reported for the parent hormone in cell models, with melanocortin-receptor-independent activity described in parts of the literature.

Which inflammatory and barrier models have been used to study KPV?

Published in-vitro work uses NF-κB reporter assays, cytokine expression in stimulated macrophage and epithelial cultures, and intestinal epithelial monolayers where transepithelial electrical resistance and tight-junction protein expression are the readouts.

How does Pure Helix verify this KPV lot?

Each lot is released against a batch-specific certificate of analysis: identity by mass spectrometry (observed mass compared with the calculated monoisotopic/average mass), chromatographic purity by RP-HPLC reported as area percent at a stated wavelength, and quantity/appearance checks on the lyophilised cake. The certificate for the exact lot shipped is linked from the COA tab and the COA database.

α-MSH(11-13)Out of Stock

KPV (α-MSH C-Terminal Tripeptide)

The compact α-MSH tripeptide with the identity data every reviewer wants.

KPV

10mg

Drag the vial to rotate the label

Batch-verifiedShips from U.S.Public COAResearch-grade

Form

Lyophilized powder

Storage & Handling

Store lyophilized at -20°C.

Ships from

United States

Select size

1 options · price per mg shown

Quantity

Price

$59.99

$59.99 per vial

$140.01 away from free shipping$200+

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Research use only

This compound is not currently available for purchase. Submit a request to help guide future inventory and testing priorities.

Form

Lyophilized powder

Storage & Handling

Store lyophilized at -20°C.

Ships from

United States

NF-κB pathway modulationCytokine expression in cultured macrophagesEpithelial-barrier in-vitro models

The compact α-MSH tripeptide with the identity data every reviewer wants.

KPV is the C-terminal tripeptide of alpha-melanocyte-stimulating hormone (α-MSH), retaining much of the parent hormone's anti-inflammatory activity in a compact three-residue scaffold. Research groups use it in cultured macrophages, keratinocytes, and intestinal-epithelial models to study NF-κB signaling, cytokine expression (TNF-α, IL-6, IL-8), and barrier-function endpoints. Supplied as a sterile lyophilized powder for reconstitution. For laboratory research use only — not for human or veterinary use.

Compound identity

KPV (α-MSH C-Terminal Tripeptide)(α-MSH(11-13))

Single Peptide—A defined chain of amino acids supplied as one compound, with its own sequence and molecular formula.

Formula

C₁₆H₃₀N₄O₄

Form

Lyophilized powder

Available sizes

10mg

Sequence

Lys-Pro-Val

Reconstitution

Per researcher protocol

Storage & Handling

Store lyophilized at -20°C.

Ships from

United States

Intended use

Research use only

Research areas

NF-κB pathway modulation
Cytokine expression in cultured macrophages
Epithelial-barrier in-vitro models

Why researchers choose Pure Helix

Independently verified for identity and purity on a batch-specific basis.
Certificates of analysis publicly accessible by lot ID — never averaged.
Sourced through qualified manufacturing partners and shipped from the United States.
Fast shipping, always tracked, shipped from the United States.

Every lot

Batch-specific certificate of analysis, retrievable by lot ID.

Open COA database →

Reference

Research and documentation

KPV molecular reference

Formula, mass, sequence and documented lots

Quality & testing methods

Identity, purity and net content methods used for every lot

How to read a certificate of analysis

Field-by-field walkthrough of a Pure Helix COA

Backordered · Stage 03 of 06

Where this lot is in the release process

03 · En Route to LabStage 03 of 06

01
Backorder confirmed
Your product is reserved from the incoming lot.
02
Arriving for testing · ~6 days
Incoming lot is expected to reach our testing queue within 6 days.
03
Sample en route to lab
A representative sample is being sent for independent analytical testing.
04
Independent testing · 3–5 days
Identity, purity, and applicable analytical testing are completed.
05
Results verified
Results are reviewed and the certificate of analysis is published.
06
Ready to ship
Verified inventory is released and your order is prepared for shipment.

Timeframes are estimates.

KPV · 10mg

$59.99