MOTS-c is a 16-amino-acid mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region, supplied here as synthetic lyophilised research material.

How is MOTS-c encoded within mitochondrial DNA?

It is translated from a short open reading frame contained in the mitochondrial 12S rRNA gene — an arrangement distinct from nuclear-encoded peptides, and part of why it is described in the literature as a mitochondrial-derived peptide.

Which metabolic pathways and models are studied?

Published in-vitro and rodent studies examine AMPK activation, the folate–methionine one-carbon cycle and downstream glucose-uptake and mitochondrial-function readouts in myotube, hepatocyte and adipocyte cultures.

How does Pure Helix verify this MOTS-c lot?

Each lot is released against a batch-specific certificate of analysis: identity by mass spectrometry (observed mass compared with the calculated monoisotopic/average mass), chromatographic purity by RP-HPLC reported as area percent at a stated wavelength, and quantity/appearance checks on the lyophilised cake. The certificate for the exact lot shipped is linked from the COA tab and the COA database.

MOTS-c (Mitochondrial ORF of the 12S rRNA-c)

The mitochondrial-derived peptide reshaping how labs think about cellular energetics.

MOTS-c

10mg

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Batch-verifiedShips from U.S.Public COAResearch-grade

Form

Lyophilized powder

Storage & Handling

Store lyophilized at -20°C.

Ships from

United States

Select size

1 options · price per mg shown

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SKU MS10Lot PH260807View COA for this lot →

Quantity

1

Price

$59.99

$59.99 per vial

$140.01 away from free shipping$200+

Independent verification

Identity & purity per lot

Free shipping on orders $200+

Fast shipping, always tracked

Ships from U.S.

Domestic logistics

Batch-specific COA

Retrievable by lot ID

By adding to cart, purchaser certifies the materials are being acquired solely for legitimate laboratory research purposes. Not for human or veterinary use.

Form

Lyophilized powder

Storage & Handling

Store lyophilized at -20°C.

Ships from

United States

Mitochondrial-derived peptide researchAMPK signaling assaysGlucose uptake in myotube culture

The mitochondrial-derived peptide reshaping how labs think about cellular energetics.

MOTS-c is a 16-amino-acid peptide encoded within the mitochondrial 12S rRNA that functions as a metabolic regulator across nuclear and cytoplasmic compartments. It is used in cultured skeletal-muscle, hepatocyte, and adipocyte models to study AMPK-mediated signaling, glucose uptake, and folate-methionine cycle intermediates as a proxy for mitochondrial-nuclear cross-talk. Supplied as a lyophilized powder. Research use only.

Compound identity

MOTS-c (Mitochondrial ORF of the 12S rRNA-c)

Single Peptide—A defined chain of amino acids supplied as one compound, with its own sequence and molecular formula.

Formula

C₁₀₁H₁₅₂N₂₈O₂₂S₂

Form

Lyophilized powder

Available sizes

10mg

Reconstitution

Per researcher protocol

Storage & Handling

Store lyophilized at -20°C.

Ships from

United States

Intended use

Research use only

Research areas

Mitochondrial-derived peptide research
AMPK signaling assays
Glucose uptake in myotube culture

Why researchers choose Pure Helix

Independently verified for identity and purity on a batch-specific basis.
Certificates of analysis publicly accessible by lot ID — never averaged.
Sourced through qualified manufacturing partners and shipped from the United States.
Fast shipping, always tracked, shipped from the United States.

Every lot

Batch-specific certificate of analysis, retrievable by lot ID.

Open COA database →

Reference

Research and documentation

MOTS-c molecular reference

Formula, mass, sequence and documented lots

Quality & testing methods

Identity, purity and net content methods used for every lot

How to read a certificate of analysis

Field-by-field walkthrough of a Pure Helix COA

Lot certificatesPH260807 Verify on Bioviridian