Semaglutide is a synthetic 31-amino-acid GLP-1 analogue derived from human GLP-1(7-37) with an Aib substitution at position 8 and a C18 fatty-diacid chain attached via a spacer at Lys26. Supplied here as lyophilised research material.

What is a GLP-1 receptor agonist, mechanistically?

The GLP-1 receptor is a class B1 GPCR. Agonist binding stabilises an active conformation that couples to Gs, raising intracellular cAMP and activating PKA, with β-arrestin recruitment studied as a parallel readout. These are the endpoints measured in cell-based signalling assays.

How is semaglutide studied in receptor signalling assays?

Typical published designs use GLP-1R-expressing cell lines with cAMP accumulation, β-arrestin recruitment or receptor-internalisation readouts, and albumin-containing media to reflect the acylation-driven binding that extends its half-life. Isolated islet and rodent models appear in the wider literature.

How does Pure Helix verify this semaglutide lot?

Each lot is released against a batch-specific certificate of analysis: identity by mass spectrometry (observed mass compared with the calculated monoisotopic/average mass), chromatographic purity by RP-HPLC reported as area percent at a stated wavelength, and quantity/appearance checks on the lyophilised cake. The certificate for the exact lot shipped is linked from the COA tab and the COA database.

GLP-1Backordered

03 · En Route to LabStage 03 of 06

Semaglutide (GLP-1 Receptor Agonist)

The reference GLP-1 tool compound — verified purity, transparent pricing.

Semaglutide

10mg

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Batch-verifiedShips from U.S.Public COAResearch-grade

Form

Lyophilized powder

Storage & Handling

Store lyophilized at -20°C. Protect from light.

Ships from

United States

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SKU SM10Lot PH260822View COA for this lot →

Quantity

Price

$49.99

$49.99 per vial

$150.01 away from free shipping$200+

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Research use only

This compound is not currently available for purchase. Submit a request to help guide future inventory and testing priorities.

Form

Lyophilized powder

Storage & Handling

Store lyophilized at -20°C. Protect from light.

Ships from

United States

GLP-1 receptor signalingcAMP / CREB reporter assaysPancreatic β-cell in-vitro models

The reference GLP-1 tool compound — verified purity, transparent pricing.

Semaglutide is a synthetic 31-amino-acid GLP-1 receptor agonist with a C18 fatty-diacid side chain and an engineered DPP-4-resistant substitution. It is used in receptor binding, cAMP accumulation, and CREB reporter assays in cell lines expressing GLP-1R, as well as in pancreatic β-cell and enterocyte in-vitro models of glucose-stimulated signaling. Supplied as a sterile lyophilized powder for reconstitution in bacteriostatic water. For laboratory research use only — not for human or veterinary use.

Compound identity

Semaglutide (GLP-1 Receptor Agonist)(GLP-1)

Peptide Hormone & Analog—A peptide that acts as a signalling hormone, or a structurally modified version of one designed to alter stability or receptor behaviour.

Formula

C₁₈₇H₂₉₁N₄₅O₅₉

Form

Lyophilized powder

Available sizes

10mg

Molecular weight

≈ 4114 Da

Reconstitution

Per researcher protocol

Storage & Handling

Store lyophilized at -20°C. Protect from light.

Ships from

United States

Intended use

Research use only

Research areas

GLP-1 receptor signaling
cAMP / CREB reporter assays
Pancreatic β-cell in-vitro models

Why researchers choose Pure Helix

Independently verified for identity and purity on a batch-specific basis.
Certificates of analysis publicly accessible by lot ID — never averaged.
Sourced through qualified manufacturing partners and shipped from the United States.
Fast shipping, always tracked, shipped from the United States.

Every lot

Batch-specific certificate of analysis, retrievable by lot ID.

Open COA database →

Reference

Research and documentation

Semaglutide molecular reference

Formula, mass, sequence and documented lots

Quality & testing methods

Identity, purity and net content methods used for every lot

How to read a certificate of analysis

Field-by-field walkthrough of a Pure Helix COA

Backordered · Stage 03 of 06

Where this lot is in the release process

03 · En Route to LabStage 03 of 06

01
Backorder confirmed
Your product is reserved from the incoming lot.
02
Arriving for testing · ~6 days
Incoming lot is expected to reach our testing queue within 6 days.
03
Sample en route to lab
A representative sample is being sent for independent analytical testing.
04
Independent testing · 3–5 days
Identity, purity, and applicable analytical testing are completed.
05
Results verified
Results are reviewed and the certificate of analysis is published.
06
Ready to ship
Verified inventory is released and your order is prepared for shipment.

Timeframes are estimates.

Semaglutide · 10mg

$49.99