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Research Use OnlyThird-Party Tested in the USABatch-Verified COAsShips from the United StatesPrecision · Purity · PerformanceResearch Use OnlyThird-Party Tested in the USABatch-Verified COAsShips from the United StatesPrecision · Purity · PerformanceResearch Use OnlyThird-Party Tested in the USABatch-Verified COAsShips from the United StatesPrecision · Purity · Performance

Research use only·All materials are supplied to qualified research purchasers for in-vitro laboratory use. Not for human or veterinary use. Research Use Agreement

GLP-3

Retatrutide (GLP-1 / GIP / Glucagon Triple Agonist)

The most-requested triple agonist in metabolic research — batch-verified and shipped from the U.S.

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SKU RT10Lot PH260501View COA for this lot →
Quantity
1
Price
$84.99
$84.99 per vial
$115.01 away from free shipping$200+
$115.01 away from free shipping$200+
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By adding to cart, purchaser certifies the materials are being acquired solely for legitimate laboratory research purposes. Not for human or veterinary use.

Form
Lyophilized powder
Storage & Handling
Store lyophilized at -20°C. Protect from light.
Ships from
United States
GLP-1/GIP/glucagon receptor signalingcAMP downstream assaysMetabolic pathway modeling

The most-requested triple agonist in metabolic research — batch-verified and shipped from the U.S.

Retatrutide is a synthetic 39-amino-acid peptide that engages three incretin-family receptors — GLP-1R, GIP-R, and the glucagon receptor — simultaneously. Research groups use it in receptor binding and downstream cAMP / β-arrestin recruitment assays to characterize the balanced pharmacology of tri-agonists relative to dual (GLP-1/GIP) and mono agonists. Its extended half-life analog design supports in-vitro stability and comparative potency work in cultured adipocyte and hepatocyte models. Supplied as a sterile lyophilized powder for reconstitution in bacteriostatic water. For laboratory research use only — not for human or veterinary use.

Research areas
  • GLP-1/GIP/glucagon receptor signaling
  • cAMP downstream assays
  • Metabolic pathway modeling
Why researchers choose Pure Helix
  • Independently verified for identity and purity on a batch-specific basis.
  • Certificates of analysis publicly accessible by lot ID — never averaged.
  • Sourced through qualified manufacturing partners and shipped from the United States.
  • Fast shipping, always tracked, shipped from the United States.
Every lot
Batch-specific certificate of analysis, retrievable by lot ID.
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Reference

Research and documentation

Retatrutide molecular reference
Formula, mass, sequence and documented lots
Retatrutide research
Retatrutide (LY3437943) research reference: triple GIP / GLP-1 / glucagon receptor agonism, molecular characteristics, the primary literature, and the analytical documentation for Pure Helix lots.
Retatrutide mechanism
How retatrutide (LY3437943) engages the GIP, GLP-1 and glucagon receptors, the signalling assays used to characterise it, and what the published potency data describe.
Retatrutide vs tirzepatide
A receptor-level comparison of retatrutide and tirzepatide: which receptors each engages, how each was characterised in vitro, and why the two are not interchangeable reference materials.
Retatrutide structure
Retatrutide (LY3437943) molecular reference: 39-residue single-chain peptide, molecular formula C221H342N46O68, calculated average mass, fatty-acid modification and what the structure implies for handling.
Retatrutide receptor targets
The three receptors retatrutide engages, where each is expressed, how activity at each is measured in vitro, and why receptor selectivity has to be profiled one receptor at a time.
Retatrutide purity testing
How retatrutide lots are tested for purity and identity: reversed-phase HPLC area percent, mass confirmation by LC-MS, what the reported content figure means, and the results published for current lots.
Reading a retatrutide COA
A field-by-field walkthrough of a Pure Helix retatrutide certificate of analysis: lot number, assay date, method, purity, content, verification code, and how to check the certificate matches the vial in front of you.
How analytical testing works
Identity, purity and net content methods used for every lot
How to read a certificate of analysis
Field-by-field walkthrough of a Pure Helix COA
Explore the pathway
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Retatrutide · 10mg
$84.99